Redox dyshomeostasis
Web15. jan 2024 · Redox homeostasis and signaling is demonstrated to be crucial in the maintenance of physiological steady state throughout the entire cell cycle [1, 2]. On the … WebIn this work, a hyaluronic acid (HA) modified nanoscale cuprous metal-organic complex (HA-CuTT) was developed to reverse P-gp-related MDR via two-way regulated redox dyshomeostasis, which was achieved by both Cu +-catalyzed generation of •OH and disulfide bonds-mediated depletion of glutathione (GSH). In vitro studies reveal that the …
Redox dyshomeostasis
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Web14. dec 2024 · Reactive oxygen species (ROS) are vital signaling molecules in cellular metabolism that are generated from numerous enzymatic reactions as by-products 1, 2. Generally, the intracellular content of... Web1. máj 2024 · Iron dyshomeostasis has been proposed to be an additional factor in AD pathology as severe cognitive decline was shown to correlate with an elevated brain iron signal in amyloid-PET positive individuals [ 6 ].
Web15. aug 2024 · Redox dyshomeostasis modulation of the tumor intracellular environment through a metabolic intervention strategy for enhanced photodynamic therapy Redox … WebLiterature investigation showed that an enhanced efficacy of chemodynamic therapy (CDT) was achieved via the regulation of both oxidizing and reducing species simultaneously (two-way regulation) since severer redox dyshomeostasis was obtained in comparison with that via one-way regulation (Li et al., 2024; Xiao et al., 2024).
WebThe redox dyshomeostasis in tumor cells induced by the [email protected] further led to the mitochondrial damage, reduction of ATP levels, and downregulation of P-gp expression, which caused increasing accumulation of DOX and the reversal of MDR.
Webthe premise of cell redox dyshomeostasis, effective repair of oxi- dative damage cannot be achieved even if there is a high con- tent of GSH in the cells, thus allowing toxic ROS accumulation.
WebThis analysis showed a clear alteration of proteins related to iron metabolism. We, therefore, focused the analysis on proteins with a key role in iron metabolism in order to understand the possible molecular mechanisms responsible for redox and iron dyshomeostasis, i.e., Tf, LCN2, HPX, SOD1, Cp, and 5-lipoxygenase (5-LOX). cool christening giftsWebRedox homeostasis, as an innate cellular defense mechanism, not only contributes to malignant transformation and metastasis of tumors, but also seriously restricts reactive … family matter artinyaWeb15. jan 2024 · Redox homeostasis and signaling is demonstrated to be crucial in the maintenance of physiological steady state throughout the entire cell cycle [1,2]. On the other hand, redox imbalance may impose adverse effects on cell metabolism, owing to the disturbance of vital signaling pathways [3]. cool chocolate boxesWeb15. jan 2024 · Intracellular redox dyshomeostasis promoted by tumor microenvironment (TME) modulation has become an appealing therapeutic target for cancer management. … cool chopperWeb28. aug 2024 · Redox homeostasis is one of the main reasons for reactive oxygen species (ROS) tolerance in hypoxic tumors, limiting ROS-mediated tumor therapy. Proposed herein is a redox dyshomeostasis (RDH) strategy based on a nanoplatform, FeCysPW@ZIF … cool chocolate brown hairWeb28. aug 2024 · Redox homeostasis is one of the main reasons for reactive oxygen species (ROS) tolerance in hypoxic tumors, limiting ROS-mediated tumor therapy. Proposed … family matter in malayWeb12. jan 2024 · Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry. ... cool chocolate maker