WebMar 21, 2024 · EP300 (E1A Binding Protein P300) is a Protein Coding gene. Diseases associated with EP300 include Rubinstein-Taybi Syndrome 2 and Menke-Hennekam Syndrome 2 . Among its related … The EP300 gene is located on the long (q) arm of the human chromosome 22 at position 13.2. This gene encodes the adenovirus E1A -associated cellular p300 transcriptional co-activator protein. EP300 is closely related to another gene, CREB binding protein, which is found on human chromosome 16 . See more Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the … See more p300 HAT functions as histone acetyltransferase that regulates transcription via chromatin remodeling, and is important in the processes of cell proliferation and … See more Mutations in the EP300 gene are responsible for a small percentage of cases of Rubinstein-Taybi syndrome. These mutations result in the loss of one copy of the gene in … See more • GeneReviews/NCBI/NIH/UW entry on Rubinstein-Taybi Syndrome • GeneCard • EP300+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more The p300 protein carries out its function of activating transcription by binding to transcription factors, and the transcription machinery. On the … See more EP300 has been shown to interact with: • BCL3, • BRCA1, • CDX2, See more • Condorelli G, Giordano A (1998). "Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation". J. Cell. Biochem. 67 (4): 423–31. See more
328572 - Gene ResultEp300 E1A binding protein p300 [ (house …
WebDescription Product name Recombinant Human KAT3B / p300 protein See all KAT3B / p300 proteins and peptides Purity > 90 % Densitometry. Affinity purified. Expression system Baculovirus infected Sf9 cells Protein length Protein fragment Animal free No Nature Recombinant Species Human Amino acids 1283 to 1673 Specifications Preparation and … WebNov 10, 2024 · E1A Binding Protein P300 (EP300) is a large protein with multiple cellular functions, including as an effector in stem cell biology. Methods We used a genetic knockdown (KD) model of EP300 in TNBC cell lines to investigate the effect on CSC phenotype, tumor growth and metastasis. how to remove contact paper from walls
Role of p300-family proteins in E1A oncogene induction …
WebNov 26, 1996 · E1A oncoproteins affect cellular gene expression and associated phenotypes indirectly through interactions with transcriptionally active cellular proteins, … WebThe dCas9-p300 CRISPR Gene Activator system is based on a fusion of dCas9 to the catalytic histone acetyltransferase (HAT) core domain of the human E1A-associated protein p300. This approach has been independently validated by the Gersbach lab (Duke University) to activate genes at both proximal and distal locations relative the … WebFeb 1, 2024 · Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Eckner, R., et al. 1994. Genes Dev. 8: 869-84. PMID: 7523245 A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Arany, Z., et al. 1995. Nature. 374: … how to remove contacts from office 365